Larotrectinib (LOXO-101)

Vendor: Abmole

Type: Molecular

SKU: M6151

$103.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
Casnumber
1223403-58-4
Formula
C21H22F2N6O2
Mw
428.44
Psmiles
OC1CCN(C1)C(=O)NC2=C3N=C(C=C[N]3N=C2)N4CCCC4C5=CC(=CC=C5F)F
Purity
99.56%
Solubility
DMSO 4.3 mg/mL
Target synonyms
ARRY-470, larotrectinib
Larotrectinib (LOXO-101)

Larotrectinib (LOXO-101)

$103.50 USD