LATS1 (phospho-Thr1079) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES15190
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;ELISA;IHC
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
9113
Human swiss prot no
O95835
Immunogen
Synthesized phosho peptide around human LATS1 (Thr1079)
Isotype
IgG
Observed band
140kD
Product weight
0.005kg
Reactivity
Human;Mouse
Recommended dilutions
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
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Product Citations
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More Info
More Info
LATS1 (phospho-Thr1079) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
