LIN28A (phospho-Ser200) rabbit pAb
Vendor: ELK Biotechnology
SKU: ES15159
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;IHC
Cellular localization
Cytoplasm . Rough endoplasmic reticulum . Cytoplasm, P-body . Cytoplasm, Stress granule . Nucleus, nucleolus . Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
79727
Human swiss prot no
Q9H9Z2
Immunogen
Synthesized phosho peptide around human LIN28A (Ser200)
Isotype
IgG
Observed band
23kD
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Recommended dilutions
WB 1:500-2000;IHC-p 1:50-300
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015],
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Product Citations
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More Info
More Info
LIN28A (phospho-Ser200) rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

