Lometrexol

Vendor: Abmole

Type: Molecular

SKU: M27736

$115.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
Casnumber
106400-81-1
Formula
C21H25N5O6
Mw
443.45
Psmiles
C1C(CNC2=C1C(=O)NC(=N2)N)CCC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Purity
≥98.0%
Solubility
DMSO ≥ 40 mg/mL
Target synonyms
DDATHF
Lometrexol

Lometrexol

$115.00 USD