MARCH1 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES6692
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IHC;IF;WB;ELISA
Cellular localization
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
55016
Human swiss prot no
Q8TCQ1
Immunogen
Synthesized peptide derived from the Internal region of human 40603.
Isotype
IgG
Observed band
32kD
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Recommended dilutions
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Background
Background
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010],
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Product Citations
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More Info
More Info
MARCH1 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

