MDM2 (Phospho-Tyr394) Rabbit pAb

Name: MDM2 (Phospho-Tyr394) Rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES8584

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA

Cellular localization

Nucleus, nucleoplasm. Cytoplasm . Nucleus, nucleolus. Nucleus . Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

4193

Human swiss prot no

Q00987

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human MDM2 (Phospho-Tyr394)

Isotype

IgG

Observed band

42kD

Product weight

0.005kg

Reactivity

Human;Mouse

Recommended dilutions

WB 1:500-2000, ELISA 1:10000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013],

MDM2 (Phospho-Tyr394) Rabbit pAb

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