Met (phospho-Tyr1234/1235) rabbit pAb

Name: Met (phospho-Tyr1234/1235) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES14967

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA;IHC

Cellular localization

Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

4233

Human swiss prot no

P08581

Immunogen

Synthesized phosho peptide around human Met (Tyr1234 and 1235)

Isotype

IgG

Observed band

145kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],

Met (phospho-Tyr1234/1235) rabbit pAb

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