MS177

Vendor: Abmole

Type: Molecular

SKU: M29378

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$414.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
MS177

MS177

$414.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Bioactivity
MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest.
Casnumber
2225938-86-1
Formula
C48H55N11O8
Mw
914.02
Psmiles
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)CCNC(=O)CCOCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)C(C)C)C
Purity
≥98.0%
Solubility
DMSO 125 mg/mL (ultrasonic)
Technical documents

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