MYPT1 (phospho-Ser668) rabbit pAb

Name: MYPT1 (phospho-Ser668) rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES14581

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA;IHC

Cellular localization

Cytoplasm . Cytoplasm, cytoskeleton, stress fiber . Also along actomyosin filaments. .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

4659

Human swiss prot no

O14974

Immunogen

Synthesized phosho peptide around human MYPT1 (Ser668)

Isotype

IgG

Observed band

130kD

Product weight

0.005kg

Reactivity

Human;Rat;Mouse;

Recommended dilutions

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Source

Rabbit

Storage

-20°C/1 year

Background

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosph

MYPT1 (phospho-Ser668) rabbit pAb

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