NDI-091143

Vendor: Abmole

Type: Molecular

SKU: M9587

$115.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
NDI-091143 is a novel potent inhibitor of human ATP-citrate lyase with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.
Casnumber
2375840-87-0
Formula
C20H14ClF2NO5S
Mw
453.84
Psmiles
COC(=O)C1=CC(=C(O)C(=C1)[S](=O)(=O)NC2=C(F)C=C(F)C(=C2)C3=CC=CC=C3)Cl
Purity
>99.0%
Solubility
DMSO 80 mg/mL
NDI-091143

NDI-091143

$115.00 USD