Niraparib (MK-4827)

Vendor: Abmole

Type: Molecular

SKU: M2215

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$103.50 USD
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For research use only — not intended for clinical or diagnostic purposes.
Niraparib (MK-4827)

Niraparib (MK-4827)

$103.50 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Bioactivity
MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1.
Casnumber
1038915-60-4
Formula
C19H20N4O
Mw
320.39
Psmiles
NC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4
Purity
99.82%
Solubility
DMSO ≥ 20 mg/mL
Target synonyms
MK-4827
Technical documents

Documents

Coa

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