Nutlin-3

Vendor: Abmole

Type: Molecular

SKU: M2185

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$540.50 USD
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For research use only — not intended for clinical or diagnostic purposes.
Nutlin-3

Nutlin-3

$540.50 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Bioactivity
Nutlin-3 is a selective MDM2 (mouse double minute 2) antagonist with IC50 of 90 nM. Nutlin-3 induces apoptosis in cancer cells. Nutlin-3 treatment induces the expression of MDM2 and p21, and displays potent antiproliferative activity with IC50 of ~1.5 μM in cells with wild-type p53 such as HCT116, RKO and SJSA-1.
Casnumber
548472-68-0
Formula
C30H30Cl2N4O4
Mw
581.49
Psmiles
CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)ClCC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl.CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Purity
99.70%
Solubility
DMSO ≥ 50 mg/mL
Technical documents

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Coa

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