NX-5948

Vendor: Abmole

Type: Molecular

SKU: M40697

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$1,265.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
NX-5948

NX-5948

$1,265.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Bioactivity
NX-5948 (BTK-IN-24) is an orally active, blood-brain barrier-penetrating, BTK-targeting degradation agent for the study of B-cell malignancies and autoimmune diseases. NX-5948 induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation.
Casnumber
2649400-34-8
Formula
C42H54N12O5
Mw
806.96
Psmiles
CN1CCN(C1=O)C2CCCN(C2)C3=CN=C(C(=N3)NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(CC6)C7=CN=C(C=C7)C(=O)NC8CCC(=O)NC8=O)C(=O)N
Purity
>99.0%
Solubility
DMSO 42 mg/mL
Target synonyms
BTK-IN-24; Bexobrutideg
Technical documents

Documents

Coa

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