ORC1 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES3085
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;ELISA
Cellular localization
Nucleus.
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
4998
Human swiss prot no
Q13415
Immunogen
The antiserum was produced against synthesized peptide derived from human ORC1L. AA range:331-380
Isotype
IgG
Observed band
100,120kD
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;
Recommended dilutions
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcr
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Product Citations
Product Citations
More Info
More Info
ORC1 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
