p27 rabbit pAb
Vendor: ELK Biotechnology
SKU: ES3103
Regular price
$148.00 USD
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Regular price
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;IHC;IF;ELISA
Cellular localization
Nucleus. Cytoplasm. Endosome . Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
1027
Human swiss prot no
P46527
Immunogen
The antiserum was produced against synthesized peptide derived from human p27 Kip1. AA range:149-198
Isotype
IgG
Observed band
27kD
Product weight
0.005kg
Reactivity
Human;Rat;Mouse;;Bovine
Recommended dilutions
WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014],
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More Info
More Info
p27 rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

