PAK4/5/6 rabbit pAb

Name: PAK4/5/6 rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES4458

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;ELISA

Cellular localization

Cytoplasm . Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

10298

Human swiss prot no

O96013;Q9P286;Q9NQU5

Immunogen

The antiserum was produced against synthesized peptide derived from human PAK4/5/6. AA range:441-490

Isotype

IgG

Observed band

80kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Source

Rabbit

Storage

-20°C/1 year

Background

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

PAK4/5/6 rabbit pAb

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