PCNA rabbit pAb
Vendor: ELK Biotechnology
SKU: ES8839
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
WB;ELISA;IHC
Cellular localization
Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
5111
Human swiss prot no
P12004
Immunogen
Synthesized peptide derived from human PCNA. at AA range: Internal
Isotype
IgG
Observed band
30-33kd
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Recommended dilutions
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008],
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Product Citations
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More Info
More Info
PCNA rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per

