PDGFRα (5D1) Mouse mAb

Name: PDGFRα (5D1) Mouse mAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: EM1336

$148.00 USD

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Available in stock (100)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

IHC

Cellular localization

Membrane

Clonality

Monoclonal

Concentration

1mg/mL

Geneid human

5156

Human swiss prot no

P16234

Immunogen

Synthetic Peptide

Isotype

IgG1

Observed band

180kDa

Product weight

0.005kg

Reactivity

Human, Mouse, Rat

Recommended dilutions

IHC 1:100-200

Source

Mouse

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Background

Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition, which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation, followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules, such as GRB2, Src, GAP, PI3 kinase, PLCγ, and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth, actin reorganization, migration, and differentiation.

PDGFRα (5D1) Mouse mAb

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