PF-04965842

Vendor: Abmole

Type: Molecular

SKU: M8090

$379.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Abrocitinib is an orally active and selective JAK1 inhibitor with an IC50 value of 29 nM. Abrocitinib reversibly inhibits JAK1 kinase by blocking its ATP-binding site. Abrocitinib (PF-04965842) inhibited TYK2 activity (IC50, 1.253 μM) and phosphorylation of STAT1, STAT3, and STAT5 after stimulation. It can be used in the study of autoimmune diseases.
Casnumber
1622902-68-4
Formula
C14H21N5O2S
Mw
323.41
Psmiles
CCC[S](=O)(=O)NC1CC(C1)N(C)C2=C3C=C[NH]C3=NC=N2
Purity
>99%
Solubility
DMSO ≥ 10 mg/mL
Target synonyms
Abrocitinib
PF-04965842

PF-04965842

$379.50 USD