PG 01

Vendor: Abmole

Type: Molecular

SKU: M7128

$828.00 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
PG 01 is a potent CFTR Cl- channel potentiator.PG01 was effective against E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 was also effective against ΔF508 (Ka 0.3 μM).PG01 increased ΔF508-CFTR Cl- currents with the addition of Forskolin. F508-CFTR Cl- current after the addition of Forskolin.
Casnumber
853138-65-5
Formula
C28H29N3O2
Mw
439.55
Psmiles
CC(C)C1=CC=C(C=C1)NC(=O)C(C2=CC=CC=C2)N(C)C(=O)CC3=CNC4=CC=CC=C43
Purity
>98%
Solubility
DMSO 43.95 mg/mL
PG 01

PG 01

$828.00 USD