Picropodophyllin (AXL1717)

Vendor: Abmole

Type: Molecular

SKU: M2411

$103.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM. Picropodophyllin binds to the intracellular tyrosine kinase domain of IGF-1R, inducing a conformational shift to an inactive state, thereby effectively inhibiting its autophosphorylation and downstream signal transduction.
Casnumber
477-47-4
Formula
C22H22O8
Mw
414.41
Psmiles
COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(O)C4=CC5=C(OCO5)C=C24
Purity
>99%
Solubility
DMSO ≥ 20 mg/mL
Target synonyms
Picropodophyllotoxin; CAS# 17434-18-3; PPP
Picropodophyllin (AXL1717)

Picropodophyllin (AXL1717)

$103.50 USD