Pirtobrutinib (LOXO-305)

Vendor: Abmole

Type: Molecular

SKU: M10604

$172.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Pirtobrutinib (LOXO-305; LY 3527727; RXC-005) is a first-in-class, highly selective, non-covalent, next-generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells.Pirtobrutinib's selectivity for BTK more than 300 times more selective than other 370 kinases. Pirtobrutinib can be used in studies related to chronic lymphocytic leukemia (CLL).
Casnumber
2101700-15-4
Formula
C22H21F4N5O3
Mw
479.43
Psmiles
COC1=CC=C(F)C=C1C(=O)NCC2=CC=C(C=C2)C3=N[N](C(C)C(F)(F)F)C(=C3C(N)=O)N
Purity
99.94%
Solubility
DMSO 60 mg/mL
Target synonyms
LY 3527727; RXC-005
Pirtobrutinib (LOXO-305)

Pirtobrutinib (LOXO-305)

$172.50 USD