PKA Iα reg rabbit pAb

Name: PKA Iα reg rabbit pAb
Brand: ELK Biotechnology
Price: 148.0 USD
Availability: InStock

Vendor: ELK Biotechnology

SKU: ES3218

$148.00 USD

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Applications

WB;IHC;IF;ELISA

Cellular localization

Cell membrane .

Clonality

Polyclonal

Concentration

1 mg/ml

Geneid human

5573

Human swiss prot no

P10644

Immunogen

The antiserum was produced against synthesized peptide derived from human KAP0. AA range:271-320

Isotype

IgG

Observed band

43kD

Product weight

0.005kg

Reactivity

Human;Mouse;Rat

Recommended dilutions

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Source

Rabbit

Storage

-20°C/1 year

Background

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncog

PKA Iα reg rabbit pAb

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