PMX-53

Vendor: Abmole

Type: Molecular

SKU: M20998

$448.50 USD
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Coa

Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
PMX-53 is a potent CD88 (C5aR) antagonist with an IC50 of 20 nM, it inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation.
Casnumber
219639-75-5
Formula
C47H65N11O7
Mw
896.09
Psmiles
CC(=O)NC(CC1=CC=CC=C1)C(=O)NC2CCCNC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CC5CCCCC5)NC(=O)C6CCCN6C2=O
Purity
>99.0%
Solubility
DMSO 100 mg/mL; Water 5 mg/mL (ultrasonic and warming)
Target synonyms
3D53; PMX53; Ac-Phe-[Orn-Pro-dCha-Trp-Arg]
PMX-53

PMX-53

$448.50 USD