Poseltinib

Vendor: Abmole

Type: Molecular

SKU: M11431

$310.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Poseltinib is an orally active, selective, irreversible small-molecule Bruton tyrosine kinase (BTK) inhibitor with an IC50 of 1.95 nM and 0.3, 2.3, and 2.4 fold selective action against BMX, TEC, and TXK, respectively. Poseltinib covalently binds to the active site of BTK (cysteine 481 residue) and effectively inhibits B cell receptor (BCR), Fc receptor (FcR), and Toll-like receptor (TLR) mediated signaling.
Casnumber
1353552-97-2
Formula
C26H26N6O3
Mw
470.52
Psmiles
CN1CCN(CC1)C2=CC=C(NC3=NC(=C4OC=CC4=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2
Purity
>99.0%
Solubility
DMSO ≥ 60 mg/mL
Target synonyms
HM71224; LY3337641
Poseltinib

Poseltinib

$310.50 USD