PROTAC Bcl2 degrader-1

Vendor: Abmole

Type: Molecular

SKU: M29577

$632.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Casnumber
2378801-85-3
Formula
C45H45BrN6O10S
Mw
941.84
Psmiles
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O
Purity
≥99.0%
Solubility
DMSO 25 mg/mL (ultrasonic)
PROTAC Bcl2 degrader-1

PROTAC Bcl2 degrader-1

$632.50 USD