PROTAC PD-1/PD-L1 degrader-1

Vendor: Abmole

Type: Molecular

SKU: M29649

$1,380.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.
Casnumber
2447066-37-5
Formula
C59H58ClN7O11
Mw
1076.59
Psmiles
CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)COC4=C(C=C(C(=C4)OCC5=CC(=CC=C5)C#N)CN6CCCCC6C(=O)N7CCN(CC7)C(=O)CCCC(=O)NC8=CC=CC9=C8C(=O)N(C9=O)C1CCC(=O)NC1=O)Cl
Purity
≥98.0%
Solubility
DMSO 150 mg/mL (ultrasonic)
PROTAC PD-1/PD-L1 degrader-1

PROTAC PD-1/PD-L1 degrader-1

$1,380.00 USD