PTEN rabbit pAb
Vendor: ELK Biotechnology
SKU: ES8470
Regular price
$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Applications
IF;WB;IHC;ELISA
Cellular localization
Cytoplasm . Nucleus . Nucleus, PML body . Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). .; [Isoform alpha]: Secreted . May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
Clonality
Polyclonal
Concentration
1 mg/ml
Geneid human
5728
Human swiss prot no
P60484
Immunogen
Synthesized peptide derived from PTEN at AA range: 251-300
Isotype
IgG
Observed band
50kD
Product weight
0.005kg
Reactivity
Human;Mouse;Rat
Recommended dilutions
IF: 1:50-200 IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000
Source
Rabbit
Storage
-20°C/1 year
Background
Background
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
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More Info
More Info
PTEN rabbit pAb
Regular price
$148.00 USD
Sale price
Regular price
Unit price
/per
