(R)-CR8 trihydrochloride

Vendor: Abmole

Type: Molecular

SKU: M21148

$856.75 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
(R)-CR8 trihydrochloride, one of the isomers of CR8, is a potent CDK1/2/5/7/9 inhibitor with anti-proliferative and pro-apoptotic effects on CML cell lines. (R)-CR8 trihydrochloride inhibited CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM ), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM).
Casnumber
1786438-30-9
Formula
C24H30ClN7O
Mw
468
Psmiles
Cl.Cl.Cl.CCC(CO)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=C(C=C3)C4=CC=CC=N4
Purity
>98.0%
Solubility
DMSO ≥ 60 mg/mL
Target synonyms
CR8, (R)-Isomer trihydrochloride
(R)-CR8 trihydrochloride

(R)-CR8 trihydrochloride

$856.75 USD