(R)-NX-2127

Vendor: Abmole

Type: Molecular

SKU: M55647

$540.50 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
(R)-NX-2127 (compound 28) is a first-in-class, orally bioavailable Bruton’s Tyrosine Kinase (Btk) degrader. (R)-NX-2127 mediates the degradation of transcription factors IKZF1 and IKZF3 through molecular glue interactions with the cereblon E3 ubiquitin ligase complex. NX-2127 degrades common BTK resistance mutants, including BTKC481S.
Casnumber
3024312-52-2
Formula
C39H45N9O5
Mw
719.83
Psmiles
C1CCN(CC1)C2=CN=C(C(=N2)NC3=CC=C(C=C3)C4CCN(CC4)CC5CCN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C(=O)N
Purity
99.76%
Solubility
DMSO
Target synonyms
compound 28
(R)-NX-2127

(R)-NX-2127

$540.50 USD