RapaLink-1

Vendor: Abmole

Type: Molecular

SKU: M28992

$1,380.00 USD
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Coa

Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity.
Casnumber
1887095-82-0
Formula
C91H138N12O24
Mw
1784.14
Purity
≥99.0%
Solubility
DMSO 178 mg/mL (Need ultrasonic and warming)
RapaLink-1

RapaLink-1

$1,380.00 USD