Recombinant Cynomolgus B2M (C-Fc)
Vendor: ELK Biotechnology
SKU: EPT175
Regular price
$259.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Accession
Q8SPW0
Apparent molecular weight
40 KDa, reducing conditions
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Description
Recombinant Cynomolgus Monkey Beta-2-microglobulin is produced by our Mammalian expression system and the target gene encoding Ile21-Met119 is expressed with a Fc tag at the C-terminus.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Molecular weight
38.8 KDa
Other names
Beta-2-Microglobulin; B2M
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background
Background
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.
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Recombinant Cynomolgus B2M (C-Fc)
Regular price
$259.00 USD
Sale price
Regular price
Unit price
/per
