Recombinant Human ALCAM (C-Fc)

Recombinant Human ALCAM (C-Fc)

Vendor: ELK Biotechnology
Item number: EPT251
Availability: In Stock
$59.00
$59.00
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Manual
Size: 10ug
Subtotal: $59.00
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Terms and Conditions

Recombinant Human ALCAM (C-Fc)

Recombinant Human ALCAM (C-Fc)

$59.00
Recombinant Human ALCAM (C-Fc)

Recombinant Human ALCAM (C-Fc)

$59.00
Size: 10ug
Description
Recombinant Human CD166 Antigen is produced by our Mammalian expression system and the target gene encoding Trp28-Ala526 is expressed with a Fc tag at the C-terminus.
Accession
Q13740
Molecular weight
82.7 KDa
Apparent molecular weight
110-125 KDa, reducing conditions
Other names
CD166 antigen; Activated leukocyte cell adhesion molecule; CD166; ALCAM; MEMD
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Manual
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM is expressed on thymic epithelium, microvascular endothelium, activated lymphocytes and monocytes, and monocytederived dendritic cells. ALCAM mediates low-affinity adhesion with itself or the cysteine-rich scavenger receptor CD6 to regulate T cell development, immunological synapses(IS), and cell migration through endothelial junctions. ALCAM on thymic epithelia mediates adhesion to CD6 on CD4+CD8+ T cells. Adhesion of ALCAM expressing antigen presenting cells and CD6-expressing T cells stabilizes the early IS, while later it enhances CD3 effects on T cell proliferation, CD25 expression, and Th1 commitment. ALCAM may influence expression or adhesion of the neuronal adhesion molecule NCAML1, both in the developing retina and invasive melanoma.

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