Recombinant Human C-C chemokine receptor type 6 (CCR6)-VLPs (Active)

Vendor: CUSABIO

Type: Proteins

SKU: CSB-MP004845HU

$6,042.00 USD
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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Abbreviation
Recombinant Human CCR6 protein-VLPs (Active)
Alternative names
CKRL3;CMKBR6;GPR29;STRL22
Buffer [rich text]
Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Expression region
1-374aa
Form
Lyophilized powder
Gene names
CCR6
Mw
42.5 kDa
Notes
The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
Organism
Homo sapiens (Human)
Protein length
Full Length
Purity
The purity information is not available for VLPs proteins.
Reconstitution [rich text]
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
Reference [rich text]
"Identification of CCR6, the specific receptor for a novel lymphocyte- directed CC chemokine LARC." Baba M., Imai T., Nishimura M., Kakizaki M., Takagi S., Hieshima K., Nomiyama H., Yoshie O. J. Biol. Chem. 272:14893-14898 (1997) "Molecular cloning and RNA expression of two new human chemokine receptor- like genes." Zaballos A., Varona R., Gutierrez J., Lind P., Marquez G. Biochem. Biophys. Res. Commun. 227:846-853 (1996) "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." Liao F., Lee H.-H., Farber J.M. Genomics 40:175-180 (1997)
Relevance
Act as a receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Act as a receptor for non-chemokine ligands such as beta-defensins.
Research area
Cancer
Sds description [rich text]
CSB-MP004845HU is detected by Mouse anti-6*His monoclonal antibody. The two bands respectively correspond to monomer, Homodimer.
Source
Mammalian cell
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Tag info
C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Target protein sequenc
MSGESMNFSDVFDSSEDYFVSVNTSYYSVDSEMLLCSLQEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNATCKLLKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRSRTLPRSKIICLVVWGLSVIISSSTFVFNQKYNTQGSDVCEPKYQTVSEPIRWKLLMLGLELLFGFFIPLMFMIFCYTFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGKMNRSCQSEKLIGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKILKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
Uniprot id
P51684
Recombinant Human C-C chemokine receptor type 6 (CCR6)-VLPs (Active)

Recombinant Human C-C chemokine receptor type 6 (CCR6)-VLPs (Active)

$6,042.00 USD