Recombinant Human CDH16 (C-6His)
Vendor: ELK Biotechnology
SKU: EPT249
Regular price
$199.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Accession
O75309
Apparent molecular weight
90-115 KDa, reducing conditions
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Description
Recombinant Human Cadherin-16 is produced by our Mammalian expression system and the target gene encoding Pro18-Ala786 is expressed with a 6His tag at the C-terminus.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Molecular weight
84.4 KDa
Other names
CDH16; Cadherin-16; Kidney-specific cadherin; Ksp-cadherin
Purity
Greater than 75% as determined by reducing SDS-PAGE.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background
Background
Cadherin-16(CDH16) is a single-pass type I membrane protein which contains six cadherin domains. Mature cadherin proteins consist of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small highly conserved C-terminal cytoplasmic domain. Cadherins are calcium-dependent cell adhesion proteins and may contribute to the sorting of heterogeneous cell types. They preferentially interact with themselves in a homophilic manner in connecting cells. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. CDH16 is exclusively expressed in kidney, where the protein functions as the principal mediator of homotypic cellular recognition. It plays a role in the morphogenic direction of tissue development. CDH16 is composed of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain. However, it lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins.
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Product Citations
More Info
More Info
Recombinant Human CDH16 (C-6His)
Regular price
$199.00 USD
Sale price
Regular price
Unit price
/per
