Recombinant Human GM2A (C-6His)
Vendor: ELK Biotechnology
SKU: EPT064
Regular price
$279.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
Product Overview
Product Overview
Accession
AAH09273.1
Apparent molecular weight
19-22 KDa, reducing conditions
Delivery condition
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Description
Recombinant Human Ganglioside GM2 Activator is produced by our Mammalian expression system and the target gene encoding Ser32-Ile193 is expressed with a 6His tag at the C-terminus.
Endotoxin
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Molecular weight
18.6 KDa
Other names
Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Redissolve
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Background
Background
Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A (HEXB). HEXB together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. GM2A accommodate several single chain phospholipids and fatty acids, is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
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More Info
More Info
Recombinant Human GM2A (C-6His)
Regular price
$279.00 USD
Sale price
Regular price
Unit price
/per

