Resmetirom (MGL-3196)

Vendor: Abmole

Type: Molecular

SKU: M3184

$149.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Resmetirom (MGL-3196, VIA-3196, resmetirom) is a potentially first-in-class, liver-targeted, orally active, selective thyroid hormone receptor (THR)-β agonist with an EC50 value of 0.21 μM. Resmetirom avoids the activation of THR-α receptors that mediate thyroid hormone activity outside of the liver, including the heart and bone. Resmetirom avoids the activation of THR-α receptors that mediate extrahepatic (including cardiac and skeletal) thyroid hormone activity and can be used in studies of non-alcoholic steatohepatitis (NASH).
Casnumber
920509-32-6
Formula
C17H12Cl2N6O4
Mw
435.22
Psmiles
CC(C)C1=CC(=NNC1=O)OC2=C(Cl)C=C(C=C2Cl)N3N=C(C#N)C(=O)NC3=O
Purity
99.87%
Solubility
DMSO 100 mg/mL
Target synonyms
VIA-3196; MGL-3196
Resmetirom (MGL-3196)

Resmetirom (MGL-3196)

$149.50 USD