Ribocil

Vendor: Abmole

Type: Molecular

SKU: M28295

$333.50 USD
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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
Ribocil is a highly selective chemical modulator of bacterial riboflavin riboswitches. Ribocil strongly inhibits GFP expression, achieving a 50% effective concentration (EC50) of 0.3 μM. Target: in vitro: Ribocil is a highly specific bioactive synthetic mimic of FMN, which competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB and inhibits bacterial growth. Ribocil-B demonstrates superior microbiological activity as compared to Ribocil-A (minimum inhibitory concentration (MIC) = 1 μg/ml versus MIC ≥ 64 μg/ml), inhibition of riboflavin synthesis (IC50 = 0.13 μM versus IC50 > 26 μM), and binding affinity to the E. coli FMN aptamer (Kd = 6.6 nM versus Kd ≥ 10,000 nM).[1]
Casnumber
1381289-58-2
Formula
C19H22N6OS
Mw
382.48
Psmiles
CNC1=NC=C(C=N1)CN2CCCC(C2)C3=NC(=CC(=O)N3)C4=CC=CS4
Purity
≥99.0%
Solubility
DMSO 12.5 mg/mL (ultrasonic)
Ribocil

Ribocil

$333.50 USD