RMC-7977

Vendor: Abmole

Type: Molecular

SKU: M54858

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$667.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
RMC-7977

RMC-7977

$667.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Bioactivity
RMC-7977 is a highly selective, reversible, tri-complex RAS inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants. RMC-7977 demonstrated potent activity against RAS-addicted tumours carrying various RAS genotypes, particularly against cancer models with KRAS codon 12 mutations (KRASG12X).
Casnumber
2765082-12-8
Formula
C47H60N8O6S
Mw
865.09
Psmiles
CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C8CC8)C(C)OC)(C)C)NC(=O)C9C1C9COC1
Purity
>99.0%
Solubility
DMSO ≥ 90 mg/mL
Target synonyms
RMC7977
Technical documents

Documents

Coa

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