SC 144 hydrochloride

Vendor: Abmole

Type: Molecular

SKU: M7273

$112.70 USD
Shipping calculated at checkout.

Documents

Coa

Available in stock (500)

  • Customs clearance fees may apply
  • Worldwide shipping available.
For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Bioactivity
SC144 hydrochloride is the first oral active GP130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, inducing phosphorylation (S782) and deglycosylation of GP130, eliminating Stat3 phosphorylation and nuclear translocation, and further inhibiting the expression of downstream target genes. SC144 hydrochloride inhibited signal transduction induced by GP130 ligand. SC144 hydrochloride induces apoptosis of human ovarian cancer cells.
Casnumber
917497-70-2
Formula
C16H11FN6O.HCl
Mw
358.76
Psmiles
C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4.Cl
Purity
>98%
Solubility
DMSO 32.23 mg/mL
SC 144 hydrochloride

SC 144 hydrochloride

$112.70 USD