SC144

Vendor: Abmole

Type: Molecular

SKU: M3001

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$471.50 USD
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For research use only — not intended for clinical or diagnostic purposes.
SC144

SC144

$471.50 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Bioactivity
SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells.
Casnumber
895158-95-9
Formula
C16H11FN6O
Mw
322.3
Psmiles
FC1=CC2=C(C=C1)[N]3C=CC=C3C(=N2)NNC(=O)C4=CN=CC=N4
Purity
99.86%
Solubility
DMSO 15 mg/mL
Technical documents

Documents

Coa

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