JTE-607 Dihydrochloride

Name: JTE-607 Dihydrochloride
Brand: Selleckchem
Price: 110.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Apoptosis

SKU: E0314-5mg

$110.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Apoptosis

Cas number

188791-09-5

Formula

C25H31Cl2N3O5.2ClH

Small target

TNF-alpha

Smiles

Cl.Cl.CCOC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC(=C(OCCN3CCN(C)CC3)C(=C2O)Cl)Cl

Storage conditions

3 years -20°C powder

Background

JTE-607 Dihydrochloride is a prodrug compound that is converted to an active form by ester hydrolysis. JTE-607 is a multiple cytokine production inhibitor that targets CPSF3 and inhibits pre-mRNA processing. JTE-607 inhibits tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50 values of 11 nM, 5.9 nM, 8.8 nM, 7.3 nM and 9.1 nM, respectively.

JTE-607 Dihydrochloride

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Product Overview

Background

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