O-Demethyl-Gefitinib

Name: O-Demethyl-Gefitinib
Brand: Selleckchem
Price: 128.0 USD
Availability: InStock

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: E0833-5mg

$128.00 USD

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Available in stock (500)

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For research use only — not intended for clinical or diagnostic purposes.

Product Overview

Big target

Protein Tyrosine Kinase

Cas number

847949-49-9

Formula

C21H22ClFN4O3

Small target

EGFR

Smiles

OC1=CC2=C(C=C1OCCCN3CCOCC3)C(=NC=N2)NC4=CC(=C(F)C=C4)Cl

Storage conditions

3 years -20°C powder

Background

O-Desmethyl gefitinib, a major active metabolite of gefitinib, is a potent EGFR (ErbB1/HER1) inhibitor, inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM, respectively.

O-Demethyl-Gefitinib

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Product Overview

Background

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