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Insulin Degludec chemical structure

Insulin Degludec

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THE SCIENCE, IN DETAIL

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Specifications
Big target
Protein Tyrosine Kinase
Cas number
844439-96-9
Formula
C274H411N65O81S6
Small target
IGF-1R
Smiles
CCC(C)C(NC(=O)CN)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC1CSSCC2NC(=O)C(NC(=O)C(CO)NC(=O)C(NC(=O)C(CSSCC(NC(=O)C(CC(C)C)NC(=O)C(CC3=C[NH]C=N3)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC4=CC=CC=C4)C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC5=C[NH]C=N5)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CSSCC(NC(=O)C(CC7=CC=C(O)C=C7)NC(=O)C(CC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(CC8=CC=C(O)C=C8)NC(=O)C(CC(C)C)NC(=O)C(CO)NC2=O)C(=O)NC(CC(N)=O)C(O)=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC9=CC=CC=C9)C(=O)NC(CC%10=CC=CC=C%10)C(=O)NC(CC%11=CC=C(O)C=C%11)C(=O)NC(C(C)O)C(=O)N%12CCCC%12C(=O)NC(CCCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC1=O)C(C)O)C(C)CC
Storage conditions
3 years -20°C powder
Scientific background
Insulin degludec is an acylated basal insulin with a unique mechanism of protracted absorption involving the formation of a depot of soluble multihexamer chains after subcutaneous injection, shows a very long duration of action, with a half-life exceeding 25 h in PK/PD studies.
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