GSK215 chemical structure

GSK215

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: E1113-5mg

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GSK215 chemical structure

GSK215

$293.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Protein Tyrosine Kinase
Cas number
2743427-26-9
Formula
C50H59F3N10O6S
Small target
FAK
Smiles
CNC(=O)C1=C(NC2=CC(=NC=C2C(F)(F)F)NC3=C(OC)C=C(C=C3)N4CCN(CC4)CC(=O)NC(C(=O)N5CC(O)CC5C(=O)NC(C)C6=CC=C(C=C6)C7=C(C)N=CS7)C(C)(C)C)C=CC=C1
Storage conditions
3 years -20°C powder
Scientific background
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader, which exerts FAK degradation in A549 non-small-cell lung cancer cells with DC50 of 1.3 nM by a strong time-dependence way and maximal degradation (Dmax) near the limit of the assay quantification (Dmax 99%).
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