DB2313 chemical structure

DB2313

Vendor: Selleckchem

Type: Immunology & Inflammation

SKU: E1519-5mg

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$148.00 USD
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DB2313 chemical structure

DB2313

$148.00 USD

THE SCIENCE, IN DETAIL

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Specifications
Big target
Immunology & Inflammation
Cas number
2170606-74-1
Formula
C42H41FN8O2
Small target
Immunology & Inflammation related
Scientific background
DB2313 is a potent inhibitor of the transcription factor PU.1, effectively blocking PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. DB2313 demonstrated significant anti-leukemic activity by inducing apoptosis in acute myeloid leukemia (AML) cells. It also increases survival rates and reduces tumor burden in vivo.
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