BBO-10203 chemical structure

BBO-10203

Vendor: Selleckchem

Type: PI3K/Akt/mTOR

SKU: E5872-1mg

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For research use only — not intended for clinical or diagnostic purposes.
BBO-10203 chemical structure

BBO-10203

$1,193.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
PI3K/Akt/mTOR
Cas number
2971769-60-3
Formula
C34H30F2N6O3S
Small target
PI3K
Smiles
CN(N=C1)C(C=C2)=C1C=C2C3=NC(C4=NN5C([C@@H](C)N(C(C=C)=O)CC5)=C4)=[C@]([C@]6=C(F)C=C(F)C=C6OCCOC)C7=C3C=CS7
Storage conditions
3 years-20°C powder 2 years-80°C in solvent
Scientific background
BBO-10203 inhibits PI3Kα and KRASG12C by covalently binding to Cys242 in the PI3Kα RAS-Binding Domain. It inhibits both GTP-bound and GDP-bound KRASG12C states, with IC50 and EC50 values of 0.031 nM and 0.02 nM respectively. This compound interferes with RAS-PI3Kα interaction, suppressing RAS-dependent PI3Kα activation. It decreases pERK levels, inhibits cell proliferation, and causes G1 phase arrest and apoptosis. BBO-10203 has potential applications in breast cancer, colorectal cancer, and non-small cell lung cancer research.
Technical documents

Documents

MSDS

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