BIEGi-1 chemical structure

BIEGi-1

Vendor: Selleckchem

Type: Protein Tyrosine Kinase

SKU: E6000-5mg

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$148.00 USD
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BIEGi-1 chemical structure

BIEGi-1

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Protein Tyrosine Kinase
Cas number
1429497-30-2
Formula
C36H37N7O3
Small target
EGFR
Scientific background
BIEGi-1 is a potent and selective binary inhibitor of EGFR that effectively blocks EGFR-catalyzed nucleotide exchange and disrupts the EGFR–Rheb interaction. It robustly inhibits both EGFR kinase activity and mTORC1 signaling in EGFR-mutant cancer cells. BIEGi-1 exhibits significant anti-proliferative effects with an IC50 of 17 nM for PC9 and 20 nM for HCC827.
Technical documents

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