PolQi2 chemical structure

PolQi2

Vendor: Selleckchem

Type: Cell Cycle

SKU: E6541-5mg

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$148.00 USD
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For research use only — not intended for clinical or diagnostic purposes.
PolQi2 chemical structure

PolQi2

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Cell Cycle
Cas number
2565638-16-4
Formula
C21H16ClN5O3S
Small target
DNA/RNA Synthesis
Smiles
O=C(C1=CC=NC=C1C2=C(OC)C=CC=C2)NC3=NN=C(S3)OCC4=NC=C(C=C4)Cl
Scientific background
PolQi2 is a PolΘ inhibitor that specifically targets the N-terminal helicase domain of PolΘ, thereby suppressing alt-EJ (alternative end-joining) repair. This compound improves the accuracy and integration efficiency of gene editing across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity. Its application is suitable for gene editing studies.
Technical documents

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