STAT3-IN-13 chemical structure

STAT3-IN-13

Vendor: Selleckchem

Type: Apoptosis

SKU: E6656-5mg

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STAT3-IN-13 chemical structure

STAT3-IN-13

$148.00 USD

THE SCIENCE, IN DETAIL

Know your product.

Specifications
Big target
Apoptosis
Cas number
2248552-86-3
Formula
C21H20N6O3S
Small target
STAT
Smiles
N#CC1=C(SC2=C1CCN(C2)C(NC3=CC=C(C=C3)OC)=O)NC(C(C=N4)=CN4C)=O
Storage conditions
3 years-20°C powder 2 years-80°C in solvent
Scientific background
STAT3-IN-13 (compound 6f) is a STAT3 inhibitor. It exhibits anti-proliferative activity and binds to the STAT3 SH2 domain with a KD of 0.46 μM. This compound inhibits STAT3 Y705 phosphorylation and downstream target gene expression. In vitro studies show STAT3-IN-13 induces apoptosis, while in vivo experiments demonstrate its ability to suppress tumor growth and metastasis. STAT3-IN-13 has potential applications in cancer research.
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